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Injection Site Issues Repeatedly injecting into the same site can cause localized lipodystrophy, where subcutaneous tissue becomes scarred and absorption becomes irregular

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Der dadurch ausgelste Calciumeinstrom frdert die Exozytose insulinhaltiger Granula

Notes This is a very common injectable lesion, with a propensity for recurrence

observed an elevated number of autophagic profiles containing cannibalized mitochondria in TEM of ISO exposed rats, strongly suggestive of increased mitophagy, though no molecular data was presented (55)