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Description

The outcomes for this secondary mechanistic analysis from SUMMIT were identified on the basis of pathophysiologic understanding of obesity-related HFpEF as variables that we hypothesized would change with tirzepatide treatment, including measures of BP, estimated BV and PV, kidney function, albuminuria, cardiac injury, inflammation and cardiac distention (reflected by NT-proBNP)

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If needed, the dose can be increased to 14 mg once daily after at least 30 days of taking the 7-mg daily dose

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Why is this new/important: Jardiance is currently approved in the US for type 2 diabetes, but not type 1

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