Therefore, establishing a definitive causal relationship between semaglutide and dysgeusia in individual cases requires careful clinical evaluation and consideration of alternative explanations
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However, based on preclinical data and early human trial findings, glucagon receptor co-activation in the context of concurrent GLP-1R and GIPR agonism is hypothesised to: Increase energy expenditure, potentially by promoting thermogenesis Enhance hepatic fat oxidation, which may reduce liver fat content Contribute to appetite suppression through central nervous system pathways These GCGR-mediated mechanisms are largely derived from preclinical and indirect human data and require confirmation in larger trials
Generally, tirzepatide is started at a low dosage and titrated gradually
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