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Early-phase weight loss trajectories frequently do not extrapolate linearly, and many promising Phase 2 results have failed to replicate in Phase 3

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Baseline and follow-up readings give a measurable signal

Control cohort patients had at least one outpatient encounter with a primary care provider or endocrinologist during the study period, a history of at least one non-GLP-1 medication prescription, and a follow-up within six to twelve months from a randomly selected index date to mirror the treatment cohort's follow-up schedule

These changes can lead to looser, more frequent stoolsparticularly in the first two to four weeks as your body adjusts