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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
Retatrutide is in Phase 3 clinical trials through Eli Lilly, and cagrilintide is in Phase 3 trials through Novo Nordisk (both as monotherapy and as part of CagriSema)
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DNA dot-blot analysis Genomic DNA from erythroblasts was extracted using phenol:chloroform:isoamyl alcohol (25:24:1) and precipitated with ethanol before dissolving in water
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