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Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
I used to order it more judiciously but as they all kept coming back positive for one or more, I now do it as standard practice
For glycemic outcomes, the distribution of absolute HbA1c changes showed greater reductions for GLP-1 users compared to metformin users, as seen in Figure 2
Add yogurt and milk when blending, or freeze the whole mix flat if you prefer
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