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An NPR report from February 2026 explored the benefits and risks of using GLP-1 medications at a normal BMI, noting that the long-term effects of these drugs in normal-weight populations are not well studied

Ongoing costs are higher

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Verdich C, Flint A, Gutzwiller JP, Naslund E, Beglinger C, Hellstrom PM et al

published a study on a rat model in which two weeks after bleomycin administration myocardial weight decreased and repeated administration led to irreversible changes in the myocardium and endothelial dysfunction, which resulted in myocardial infarction