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Constant, non-pulsatile GH rise (as occurs with synthetic GH use) can lead to receptor desensitization, where target tissues become less responsive to growth hormone over time

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The Pros and Cons of GLPs for Menopause Weight Loss Like any medical intervention, GLP-1s come with both benefits and drawbacks, especially when used during menopause

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10.1016/j.phrs.2022.106320 12 BoccardoF.CasabonaF.De CianF.FriedmanD.VillaG.BoglioloS.et al (2009)