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it's a fundamental piece of knowledge that separates ambiguous data from breakthrough discoveries

Without targeted interventions to restore mitochondrial transport pathways and quench this raging oxidative fire, patients remain trapped in a devastating state of chronic cellular depletion and systemic hyper-reactivity, unable to break the cycle of fatigue and inflammation

The mechanisms are biologically plausible

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However, many studies were conducted in populations with mild to moderate symptoms and lacked active antidepressant comparators, limiting conclusions regarding relative efficacy