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Circulation 146(24):18821894 Mary P, Curtis R (2010) Weighing risks and benefits of liraglutide the FDAs review of a new antidiabetic therapy

So the older "oral does nothing" framing has softened

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The constant switching prevents the body from establishing a predictable rhythm and makes side effects harder to manage

Deanfield J, Lincoff AM, Kahn SE et al (2025) Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial