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The consideration of cysteine during these simulations were important, as cytosolic cysteine is the rate limiting amino acid precursor for synthesis of GSH, via the -glutamylcysteine synthetase (GCS) enzyme, and this is a function of its reduced concentration compared to the other precursors, glycine and glutamate

McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H

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& Despres, J

Phospholipase iPLA2 averts ferroptosis by eliminating a redox lipid death signal