Why to avoid with MTHFR: Requires multiple conversion steps to become active MTHFR mutations impair these conversions Contains cyanide (though small amount) Least bioavailable form Found in most cheap multivitamins and fortified foods Bottom line: Choose methylcobalamin, hydroxocobalamin, or adenosylcobalamin instead
However, not everyone converts synthetic forms efficiently, particularly those with higher metabolic stress, liver strain, or certain genetic variations including the MTHFR mutation
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In fact, a B12 deficiency can sometimes lead to weight loss due to reduced appetite
With regular B12 supplementation, you will turn the corner