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(3) If you have been diagnosed or previously treated for any gallbladder disease, do not use semaglutide without first talking to a healthcare provider

Adding semaglutide to tirzepatide would, in theory, increase total GLP-1 receptor occupancy without adding meaningful GIP activationpotentially increasing side effects without proportional clinical benefit

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Even when people want to lose more weight, they may have strong reasons to discontinue use of a GLP-1

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