Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)
C.FinkelsteinJ.et al
In 2024, the global market was led by Ozempic, contributing up to 55% of the global revenue
While exploring whether oral semaglutide is effective for weight loss, you'll find it works by mimicking a hormone called GLP-1, which regulates both blood sugar and appetite
It has been shown that p38 MAPK, c-fos (Zhang et al., 2021) and TNF- (Zheng et al., 2023b) are all involved in the inflammatory response, and they are widely associated with the pathogenesis of inflammatory diseases, serving a key role in regulating the inflammatory immune process
While these medications are beneficial, they have potential side effects, so understanding natural ways to support GLP-1 can be empowering and sustainable
