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Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

For example, the combination of metformin with combined oral contraceptives has shown enhanced benefits on hormonal and metabolic parameters compared to either treatment alone

doi: 10.1684/mrh.2020.0465 124 JacksonC

For example, advancing clinical trials of combination therapeutic strategies utilizing EZH2 inhibitors and ferroptosis inducers to validate their synergistic efficacy in cancer treatment, or developing lipid metabolism-based biomarkers e.g., SCD1 expression level for identifying EZH2 inhibitor-sensitive patient populations

Rodent healing differs from human healing in various ways, and dose extrapolation involves assumptions that may not hold perfectly