Drug holidays are often discussed in the context of attention-deficit hyperactivity disorder (ADHD) treatment, especially in children and adolescents
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Nausea and digestive discomfort Eat three balanced meals a day based on whole foods Choose easy-to-digest foods during the first few weeks, such as scrambled eggs, white fish, and cooked vegetables Stay well hydrated between meals (aim for 2 litres daily) Limit the intake of ultra-processed foods and takeaways Consider ginger tea or supplements, which may help reduce nausea in some people Fatigue Ensure adequate protein intake at each meal Include iron-rich foods like red meat and spinach alongside vitamin C sources Maintain consistent sleep habits Dont skip meals, even if your appetite is reduced Changes in appetite Maintain three balanced meals a day based on whole foods, even if hunger is low Include a protein-rich food at each meal, roughly a palm-sized portion Include plenty of non-starchy vegetables to maximise the nutrient density of meals Plan healthy snacks for times when hunger might increase Most transition-related side effects resolve within 2-4 weeks as the body adjusts to the new medication

Thats still within the range thats been studied
doi: 10.1007/s40200-020-00518-z 171 AkhbariMJabbariMAyatiMHNamaziN
In contrast, SGLT2i have metabolic effects on the myocardial and renal cells that mimic energy starvation, simulating autophagy and other changes that counteract the progression of HF
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