Retatrutide is a triple receptor agonist (GLP-1, GIP, and glucagon) that produced 24.2% average weight loss over 48 weeks in Phase 2 trials
In September 2023 the FDA placed BPC-157 in Category 2 of its 503A interim bulk-substances policy, citing immunogenicity and peptide-characterization concerns, effectively excluding it from the 503A compounding bulk-substances list
Whilst GLP-1 medications are often used long-term, particularly for diabetes management, they're not necessarily lifelong for everyone
Reduction of new onset of atrial fibrillation in patients treated with semaglutide: an updated systematic review and meta regression analysis of randomized controlled trials
Breve, B
Tirzepatide (Mounjaro and Zepbound) produces larger total weight loss than semaglutide on average, which means larger absolute muscle loss in numbers, even if the proportional loss is similar