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Muni, MD MSc FRCSC, associate professor and vice chair of Clinical Research in the Department of Ophthalmology and Vision Sciences at the University of Toronto in Canada, and principal investigator of this study explained to Medical News Today

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Up-regulation of mGlu2 receptors was observed in cultured DRG neurons isolated from 30-day acetyl-l-carnitine-treated -GalA knockout mice, which was no longer detectable in DRG neurons isolated 30 days after the end of treatment, hinting at an additional mechanism being responsible for the long-term analgesic effect [35]