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In conclusion, taking advantage of the elevated GSH in TME, our study affords a new strategy for targeted chemotherapy of ATC with high selectivity and reduced adverse effects
These compounds were described not only as substrates for glutathione production but also as metabolically active participants in pathways related to methylation and redox signaling
That's a genuinely unusual profile for a three-amino-acid molecule most peptides this size have a narrow, specific target
References FDA
One final convergence point of these related signaling events, is the initiation of the p38 MAPK and MAPK/ERK1/2 signaling pathways, that causes changes in gene expression and can modify cell metabolism and proliferation (106, 124)
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