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A 2023 meta-analysis of acromegaly cohorts, Xiao et al

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It stimulates GH release without significantly affecting cortisol, prolactin, or other off-target hormonesmaking it more tolerable than older peptides like GHRP-6 or GHRP-2

This activates a G-protein-coupled signaling cascade that raises intracellular calcium and triggers growth hormone release

The road to inhibition of these factors has three steps: Restore, Maintain, and Advance