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The GIP receptor activation in tirzepatide may enhance weight loss efficacy, but it also introduces distinct tolerability considerations

Swisher SG , Roth JA, Nemunaitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mack M, Merritt JA, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB Jr, Richli WR, Savin M, Schrump DS, Shin DM, Shulkin A, Walsh GL, Wait J, Weill D, Waugh MK

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Effects on Cortisol and Prolactin GHRP-2 produces moderate stimulation of the ACTH-cortisol axis and prolactin secretion

Its also prudent to coordinate care with mental health professionals when appropriate

Tomofuji, et al., Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet