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The review confirmed that glutathione peroxidases detoxify peroxides by a reaction coupled to GSH oxidation to GSSG with GSSG converted back to GSH by glutathione reductase and NADPH

However, reperfusion can cause further damage to cardiac tissue, including cytokine production, neutrophil infiltration, and ROS production, called I/R injury [89]

Aside from its detoxification role, it is important for a variety of essential cellular reactions

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