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It plays a central role in redox homeostasis, detoxification of reactive oxygen species, and maintenance of cellular thiol balance across virtually every tissue type in the body
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For example, if you rotate the wheel 30 times to select a 2.5 mg dosage, rotate it 15 times to select a 1.25 mg dosage, which is a microdose
Risk is further increased in patients with: Pre-existing cardiac conditions Electrolyte imbalances (e.g., low potassium or magnesium) A personal or family history of long QT syndrome Concurrent use of CYP2C19 inhibitors (e.g., omeprazole, esomeprazole, cimetidine), which can raise escitalopram levels Where a combination of QT-prolonging medicines is clinically necessary, a baseline ECG and electrolyte check should be considered
doi: 10.1016/j.jaccas.2019.12.013 575 BenjaminEJBlahaMJChiuveSECushmanMDasSRDeoRet al
Excessive pro-inflammatory cytokines suppress the negative feedback of the HPA axis, boost the permeability of the blood-brain barrier, decrease the synthesis of neurotransmitters such as serotonin (5-HT), and ultimately lead to the onset of depression (Haroon and Miller, 2017
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