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White, A

PLoS One 10 (4), e0123454

Results After exclusions and propensity score trimming, the cohort consisted of 145 410 patients who started GLP1 receptor agonist treatment and 291 667 patients who started DPP4 inhibitor treatment (fig 1)

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Pfizer discontinued danuglipron but re-entered obesity development through the acquisition of Metsera Mazdutide was approved in China for both obesity and type 2 diabetes Semaglutide received MASH indication in the U.S

Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures