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The TECOS trial showed no difference between the placebo and a sitagliptin group (Table 2) [47,48,49]

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(2001) which examined how rats on a dietary restriction (DR) program had significantly increased amounts of BDNF in their hippocampus, cerebral cortex, and striatum compared to controls

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Animal studies involved naturally aged male C57BL/6 mice that were 20 months old and younger controls that were 3 and 13 months old