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Clinical trial design must account for this heterogeneity, possibly incorporating patient stratification based on imaging, genetic risk factors (e.g., APOE or TREM2 variants), or peripheral cytokine profiles
PMID: 24355990
Across the 39 companies we reviewed, 87% offered structured wrap-around support, including one or more of the following: Tracking and goal-setting tools Meal plans and recipes Nutrition counseling Behavioral health tools Virtual support groups or community chat Virtual workouts and exercise plans Lab monitoring 4
Throughout the follow-up period, HbA1C levels remained consistently higher in the GLP-1 RAs group (Figure S1)
Insulin resistance severity influences treatment response
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