The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier
Materials 5(9):16611685 Wakamatsu K, Zippin JH, Ito S (2021) Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis
There is some research that suggests vitamin C injections might help reduce side effects and improve quality of life
Selective Effects: Ipamorelin exerts its effects primarily on growth hormone release, with minimal impact on other hormones such as thyroid-stimulating hormone, luteinizing hormone, and prolactin
Compounded lipotropic preparations are not reviewed or approved by the FDA for safety, effectiveness, or quality before they are marketed
By itself, however, a B12 injection isnt likely to produce a significant amount of weight loss