The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., 2013)
10.1093/pcp/pcx180
1,3,53,54 Perhaps the most widely known trial evaluating LVRS is the National Emphysema Treatment Trial (NETT), which is considered one of the largest LVRS trials
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It remains available as a research compound
Such architecture thus enables high loading capacity and prolonged blood circulation of therapeutic agents, and its efficient accumulation in brain lesions