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The meta-analysis included 16 studies including patients with asymptomatic hyperuricemia and/or gout treated with febuxostat and were compared with placebo/allopurinol, demonstrating a significant reduction in renal events (doubling of serum creatinine concentration and/or entry into renal replacement therapy): HR 0.56, 95% CI 0.370.84, p = 0.006 and a slight decrease in the fall of glomerular filtration rate (0.90 ml/min/1.73 m2) and in albuminuria.49 Like the observed with allopurinol, there is currently insufficient evidence to suggest treatment with febuxostat for renal or cardiovascular protection in patients with asymptomatic hyperuricemia
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Available from: Tandvrds- och lkemedelsfrmnsverket (TLV) (2015) Lyxumia ingr i hgkostnadsskyddet med begrnsning
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On the other hand, consumption of fruits and vegetables
A 5 to 10 percent change is usually sufficient
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