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The metabolite response of urchins from the barren populations involves a range of metabolic pathways, which included glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, nucleotide metabolism, fatty acid synthesis and oxidation and amino acid metabolism (Fig

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The tumor in the 16 cases had an average maximum diameter of 8.55 cm, with a median of 5.7 cm, compared to a previous study reporting a median tumor size of 3.2 cm [2]