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Depending on the starting weight of the patient, it will likely take between one year and 18 months before the final goal weight has been achieved, but once the medication is being administered at full dose and the patient is able to maintain a strict diet and exercise plan, the weight will continue to decrease until that point

Cost & Coverage Semaglutide Cost Without Insurance: What You'll Actually Pay Medically reviewed by:Medura Clinical Team Last updated:July 21, 2026 If you've started looking into semaglutide for weight loss, you've probably already run into a confusing spread of numbers

Ozdemir R, Gokce IK, Tekin S, Cetin Taslidere A, Turgut H, Tanbek K, et al

While GLP-1 medications can be administered at any time of day (consistent with prescribing information), some patients report personal preference for evening administration

Phase II clinical trial results demonstrated: Body weight reduction of up to 2% at 48 weeks ( vs 2.1% placebo ) 83% of participants achieved 15% body weight loss at highest dose HbA1c reduction of up to 02% in Type 2 Diabetes participants ( vs 0% placebo ) Normalization of liver fat in 86% of participants with hepatic steatosis Reduction in systolic blood pressure averaging 6-8 mmHg Phase II findings are preliminary