There may be unforeseen interactions or cumulative effects that could impact overall safety
Medication interactions : Certain medications, such as metformin and some heartburn drugs, can interfere with B vitamin absorption
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(2) F M Ng, W J Jiang, R Gianello, S Pitt, and P Roupas (2000)
Side effects are usually mild and temporary
Large trials have demonstrated that these agents reduce cardiovascular events in patients with cardiovascular disease and improve outcomes in heart failure, kidney disease and metabolic dysfunction-associated steatohepatitis