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The half-life difference between the two forms is roughly 8 days versus minutes, so the dosing frequency mismatch is dramatic

This can lead to inconsistencies in drug efficacy and safety

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As for GLP-1 side effects related to vision, a study of more than 16,000 patients published in JAMA Ophthalmology found a higher risk of a rare eye condition called NAION in semaglutide users