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The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79

2012 May;103(4):257-9

doi: 10.1016/j.cmet.2016.02.005

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Joint discomfort: Elevated GH can cause joint stiffness, achiness, or mild pain