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In terms of metformin, unfortunately no trials are reported in this meta-analysis

The relationship between weight and sleep is complicated - poor sleep quality definitely impacts weight loss and gain, and there is a need for trials in this space to better assess the potential impact

Because this side effect occurs consistently, it has led to interest in topiramate for obesity, but the risks associated with the drug make off-label use for weight loss inappropriate outside specialist settings

Common side effects of both medications include: Nausea

This dual action reduces appetite and food intake but can trigger mild dehydration if fluid intake is insufficient

An optimal strategy for managing people who are overweight/obese with or without T2D should consider a combination of interventions lifestyle, medication and metabolic surgery.