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KDOQI clinical practice guideline for diabetes and CKD: 2012 update

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[1] [2] Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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In hepatocyte cultures, retatrutide produces a complex pattern reflecting the competing effects of glucagon receptor activation (raising glucose output and lipid oxidation) and GLP-1 signalling (lowering glucose output and lipogenesis)

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