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GLP-1 receptor agonists, like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), are changing this paradigm

Preclinical work with GLP-1R/GIPR/GcgR triple agonists showed that a balanced triple agonist produced greater body-weight loss than semaglutide, tirzepatide, and dual co-agonists in diet-induced obese mice, reducing weight to near-lean levels at the highest doses

True plateaus occur at stable weight