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Wiczew D, Szulc N, Tarek M (2021) Molecular dynamics simulations of the effects of lipid oxidation on the permeability of cell membranes

Human pharmacokinetic data from the 1999 PK/PD study (PMID: 10496658) documented a plasma half-life of approximately 2 hours in humans

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Given the central pathogenic role of IL-6 in AP, both clinical and experimental studies suggest that targeting the IL-6 signaling pathwayparticularly its trans-signaling armmay represent a promising therapeutic approach

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