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Studies Linking GLP-1 Medications to NAION Several peer-reviewed studies have confirmed an increased risk of NAION in patients taking GLP-1 drugs: Harvard Medical School & Mass General Brigham Study (JAMA Ophthalmology, 2024) 9% of diabetic patients taking semaglutide developed NAION, compared to 1.8% on other diabetes drugs (a 4-fold increased risk)
GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimers disease: association hypothesis for an uncommon genetic variant
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Cerebrolysin improved nerve fiber parameters in a diabetic neuropathy mouse model
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Thus, the total GSH level in the brain determines the ROS buffering capacity and protects neurons from oxidative damage
