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Given the lack of liver GLP-1R expression (136), the potential mechanism of actions of GLP-1R agonists in NASH may be related to the indirect beneficial effects on body weight, IR and reduction in metabolic dysfunction, lipotoxic effects and inflammation (49, 137)
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Ayora M, Fraguas D, Abreg-Crespo R, Recio S, Blasco MA, Moises A, et al
The concern is legitimate
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SchwartzAJDasNKRamakrishnanSKJainCJurkovicMTWuJet al
Each one plays a unique role, but together they form an interconnected defense cycle that continuously regenerates itself
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