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By comparison, PUF-8s PUM repeats R8-R5 bind to the 5-UGUA sequence, while PUM repeats R3-R1 bind to the AUA-3 sequence with central fifth base stacked with the fourth base and not recognized by the protein (Bhat et al., 2019)

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(1997) reported that IGF-1 LR3 supported protein turnover in tumor-bearing rats but also increased tumor growth in that model