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The medication is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that works by enhancing glucose-dependent insulin secretion, suppressing glucagon release, and slowing gastric emptying

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Gastroparesis Retatrutide slows gastric emptying

PMID 40934115, DOI 10.1056/NEJMoa2500969, OASIS 4

CJC without DAC lacks this linker, has a half-life of ~30 minutes and elicits physiological pulsatile GH peaks

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