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The analysis of any congenital malformations included seven studies with 42,282 exposed pregnancies and 723,892 comparator pregnancies

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Target: Maintain 200 mg per dose, 23 weekly, through weeks 312

The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]

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