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Stein LR, Imai S

Numerous proteolytic enzymes are involved in the GLP-1 peptide degradation pathways 34 and eliminating all possible cleavage sites via amino acid mutation, without dramatically impacting on GLP-1R activity, would be particularly challenging, or indeed may not be possible

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Protein helps to: Build, maintain, and repair muscle Boost immunity Support brain development and function Build stronger bones Deliver oxygen to tissues And is an energy source. The American College of Sports Medicine recommends in grams of protein per kilogram of body weight per day: 1.2 2.0 g/kg for individuals who are routinely active 1.0 1.2 g/kg for healthy older adults 1.2 1.5 g/kg for older adults with acute or chronic disease Up to 2 g/kg for older adults with severe illness/marked malnutrition 1.0 1.5 g/kg for middle-aged men and women This range helps maintain muscle mass, which is vital during periods of reduced calorie intake

The medication appears most effective as part of a comprehensive approach to weight management rather than a short-term solution

They reported mild gastrointestinal symptoms and no substantial changes in disease activity scores (104, 105)