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16 A recent retrospective analysis of all SGLT-2 inhibitors and their potential effects on metabolic parameters demonstrated a decrease in LDL-C, a decrease in TG, and an increase in HDL-C across the class of medications

The mechanism likely involves insulin pathway normalization: GLP-1 receptors in the hypothalamus improve glucose handling, reducing compensatory hyperinsulinemia that suppresses reproductive hormone release

This findings indicate that an additive effect of lifestyle modifications and liraglutide 3 mg/day might exist (70)

Follow-up treatments every few months may help maintain the benefits over time

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