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In G-6-PD deficiency , there is a shortage of NADPH, and RBCs can not neutralize the oxidant stress and are hemolyzed

33 HiraoJ.NiinoN.ArakawaS.ShibataS.MoriK.AndoY.et al (2010)

Supplementation should generally be reserved for documented deficiencies, as excessive supplementation can cause side effects

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