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Beyond collagen, GHK-Cus effects on the extracellular matrix extend to elastin (30% increase), decorin (302% increase at 1 nanomolar concentration), glycosaminoglycans, dermatan sulfate, and chondroitin sulfate
However, this therapeutic effect is reversed by administration of the PI3K inhibitor LY294002, suggesting that sipeimine combined with rosavin regulates ferroptosis via the PI3K/AKT/Nrf2 pathway, addressing PM 2.5 -induced damage to the lungs [103]
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