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Over time, clinical use and research showed that these appetite-related effects could be harnessed more directly for weight management when used at appropriate doses under medical supervision

It was backed by the era's leading medical minds

No validated human pharmacokinetics A human half-life, bioavailability, tissue distribution, metabolic pathway and exposure-response relationship have not been established through a published clinical programme

The ladder above is not a validated human dose

This early dip is believed to reflect hemodynamic changes rather than actual kidney damage