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Abstract Pathogenesis of diabetes mellitus involves scores of different factors, out of which Glucagon like factor-1 (GLP-1) plays a foremost role

References: Fox CK, Barrientos-Prez M, Bomberg EM, et al

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More broadly, any product marketed for weight loss may create delays in proper diagnosis or treatment if a person relies on it instead of seeking medical care for obesity, insulin resistance, or diabetes

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Providers should monitor weight trajectory , GI tolerability (nausea, vomiting, constipation) , signs of pancreatitis (persistent severe abdominal pain vomiting), gallbladder disease (RUQ pain, fever, jaundice), hydration/renal function when clinically indicated (risk of AKI with severe GI effects), blood pressure , and glucose metrics (especially if combined with insulin or sulfonylureas due to hypoglycemia risk)