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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol
During stable dosing (months 4+) Once you are on a stable dose and side effects have lessened, Protocol 1 is usually sufficient
However, NICE guideline NG28 specifies continuation criteria: treatment should be reviewed after approximately 6 months and only continued if you've achieved both a reduction in HbA1c of at least 11 mmol/mol (1%) and weight loss of at least 3%
Take once every two days 2
Brain penetrance The ability of GLP-1RAs to enter the CNS is debated, and we refer readers to ref 9 17 98 99 for a more extensive discussion of the topic
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